Xiaokun Liu | BIG/CNCB

About Me

Hi, I am Xiaokun Liu, a postdoctoral researcher in bioinformatics at the Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS) / National Genomics Data Center (NGDC). I received my B.S. in Biotechnology from the University of Science and Technology Beijing (USTB) in 2020, where I developed a strong foundation in molecular biology and data-driven life sciences. I then joined BIG to pursue my Ph.D. in Bioinformatics under the supervision of Dr. Xu, which I completed in January 2026. My doctoral research focused on 3D genome, during which I developed Footprint-C, a novel Hi-C method for mapping chromatin interactions with transcription factor resolution. Following graduation, I continued as a postdoc in the same group to further explore 3D genome folding. My work lies at the intersection of genomics and computational biology, with a long-term goal of deciphering the grammar of the genome.

Interests

3D genome: C-family methods
Computational technology: deep learning, LLM

Publications

Science Advances

Architectural transcription factors collectively shape nuclear radial positioning of chromatin contacts

Juan Bai#, Hanhan Wei#, Siling Hu#, Yi Guo, Qifan Zhang, Xiaokun Liu & Chenhuan Xue* (#Co-first authors *Corresponding authors)

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Nature Communications

Footprint-C reveals transcription factor modes in local clusters and long-range chromatin interactions

Xiaokun Liu#, Hanhan Wei#, Qifan Zhang, Na Zhang, Qingqing Wu & Chenhuan Xu* (#Co-first authors *Corresponding author)

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